The extreme type on the proportion out of CO and GC events noticed collectively chromosomes aided by the negative relationships anywhere between CO and you may GC rates therefore be seemingly contradictory towards the “depending design” while you are help a very dynamic one to related to a changeable DSB fix path otherwise DHJ solution across genomes
It is very fascinating to remember that the seen patterns away from CO and you will GC shipping along chromosomes is inform us regarding patterns proposed to explain chiasma interference. The “depending model” assumes on one double-strand vacations occur separately, which a predetermined and you can organism-particular matter (m) regarding noncrossovers (GC incidents) exists anywhere between neighboring crossovers , . A later on extension of the model incorporated the potential for good small fraction off meiotic crossovers of the next path which is not susceptible to interference .
At a 100-kb scale, we have shown that CO, and to a much lesser degree GC, are not randomly distributed across chromosomes. (more…)